[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"$fKS9S6E_eJ4MfwSeAiQ2fN4pcmArQljpvpy4qxUh0L-I":3},{"code":4,"msg":5,"data":6},200,"操作成功",{"id":7,"title":8,"content":9,"digest":10,"source":10,"coverPath":11,"thumbsCoverPath":12,"isTop":13,"isShow":14,"baseClick":13,"clickCount":15,"createTime":16,"typeId":17,"isNewest":18,"newsInfoTypeRespVo":19,"voiceUrl":22,"voiceSize":23,"taskId":24,"releaseTime":25,"titleEn":26,"contentEn":27,"voiceUrlEn":28,"taskIdEn":29,"voiceSizeEn":30},1428,"AI“重编程”癌症干细胞促其自毁","\u003Cp>\u003Cstrong class=\"ql-lineHeight-1-75\" style=\"font-size: 18px; color: rgb(255, 153, 0);\">美国加州大学圣迭戈分校研究团队开发了一种摧毁癌症干细胞的新方法，该方法在结肠癌的研究中取得了突破。他们利用人工智能精准识别治疗靶点，并通过“重编程”癌症干细胞促使其自我毁灭。这种方法仅针对癌细胞，不影响周围组织，有望成为比现有治疗方法更安全、更精确的替代方案。相关成果20日发表在《细胞·报告医学》期刊上。\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 18px;\" class=\"ql-lineHeight-1-75\">癌症干细胞，这些隐藏在肿瘤中的“变色龙”细胞，一直是癌症治疗中的难题。它们不仅能躲避现有的治疗手段，还能帮助癌症复发、扩散，甚至对最先进的疗法也有强大的抵抗力。\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 18px;\" class=\"ql-lineHeight-1-75\">为了应对这些顽固的癌细胞，研究团队创造了一个名为癌症相关节点分化靶向（CANDiT）的机器学习工具。该工具能够根据特定肿瘤的独特基因组，识别新的治疗靶点。CANDiT的工作原理是从一个关键基因入手，这个基因对健康细胞的正常生长至关重要，但在侵袭性癌症细胞中通常缺失。接着，CANDiT会深入分析与该基因相关的基因网络，并提出可通过调控这些网络恢复细胞健康的潜在治疗靶点。\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 18px;\" class=\"ql-lineHeight-1-75\">团队选择结肠癌中的关键基因CDX2作为研究起点。利用CANDiT工具，他们对4600多种不同的肿瘤样本进行了基因组扫描。通过分析，团队意外地发现了一个新的治疗靶点——PRKAB1蛋白质，它的作用是促进细胞在应激状态下的生存。随后他们利用现有药物激活PRKAB1，从而成功恢复了结肠癌干细胞中CDX2基因的功能。\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 18px;\" class=\"ql-lineHeight-1-75\">然而，这些癌症干细胞仿佛无法忍受失去的“癌症身份”，没有停留在恢复正常细胞状态上，而是选择了自我毁灭。\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 18px;\" class=\"ql-lineHeight-1-75\">为了验证这一方法的临床潜力，团队将药物测试推广到患者来源的类器官模型中。他们还开发了一种基因签名，即一种可通过基因激活模式预测患者对这种治疗反应的方法。通过对2100多名患者的模拟分析发现，CDX2基因功能恢复后，结肠癌患者的复发和死亡风险可降低50%。\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(187, 187, 187);\">【新闻来源】科技日报 \u003C\u002Fspan>\u003Ca href=\"http:\u002F\u002Fhealth.people.com.cn\u002Fn1\u002F2025\u002F1022\u002Fc14739-40586853.html\" rel=\"noopener noreferrer\" target=\"_blank\" style=\"color: rgb(187, 187, 187);\">http:\u002F\u002Fhealth.people.com.cn\u002Fn1\u002F2025\u002F1022\u002Fc14739-40586853.html\u003C\u002Fa>\u003C\u002Fp>\u003Cp class=\"ql-align-justify\">\u003Cspan style=\"color: rgb(187, 187, 187);\">（本网转发此文章，旨在为读者提供更多的信息资讯，所涉内容不构成投资、消费建议。文章事实如有疑问，请与有关方核实，文章观点非本网观点，仅供读者参考。）\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>","","https:\u002F\u002Fimage.51xinwei.com\u002F2025\u002F10\u002F4730f6810564472f9b483bee1df90664\u002FAI领域.jpg","https:\u002F\u002Fimage.51xinwei.com\u002F2025\u002F10\u002Fthumbs\u002F4730f6810564472f9b483bee1df90664\u002FAI领域.jpg",0,1,84,"2025-10-23 18:41",2,false,{"id":17,"name":20,"enName":21},"芯位视野","Xinwei Vision","https:\u002F\u002Fxinwei-dev-test.oss-cn-shenzhen.aliyuncs.com\u002Fintelligent\u002Faudio%3Abcf38725-986c-4356-af9c-545faa6d53a4%3A0.wav?Expires=1761220550&OSSAccessKeyId=LTAI5tNvY2RkKjZw4LLWsrPK&Signature=4KFohkO3s9lae7kavTtW2mM1VBE%3D",4220004,"bcf38725-986c-4356-af9c-545faa6d53a4","2025-10-23 18:39","AI \"Reprograms\" Cancer Stem Cells to Cause Their Self-Destruction","\u003Cp>\u003Cstrong class=\"ql-lineHeight-1-75\" style=\"font-size: 18px; color: rgb(255, 153, 0);\">A research team from the University of California, San Diego has developed a new method to destroy cancer stem cells, which has made breakthroughs in colon cancer research. They used artificial intelligence to accurately identify treatment targets and \"reprogram\" cancer stem cells to cause their self-destruction. This method targets only cancer cells without affecting surrounding tissues and is expected to become a safer and more precise alternative to existing treatments. The related findings were published on the journal Cell Reports Medicine on the 20th.\u003C\u002Fstrong>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 18px;\" class=\"ql-lineHeight-1-75\">Cancer stem cells, these \"chameleons\" hidden within tumors, have always been a challenge in cancer treatment. They not only can evade existing treatment methods but also help cancer recur, spread, and even show strong resistance to the most advanced therapies.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 18px;\" class=\"ql-lineHeight-1-75\">To address these stubborn cancer cells, the research team created a machine learning tool called Cancer-Associated Node Differentiation Targeting (CANDiT). This tool can identify new treatment targets based on the unique genome of a specific tumor. CANDiT works by starting with a key gene that is essential for the normal growth of healthy cells, but is usually missing in aggressive cancer cells. Then, CANDiT deeply analyzes the gene network related to this gene and proposes potential treatment targets that could restore cell health through regulation of these networks.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 18px;\" class=\"ql-lineHeight-1-75\">The team chose the key gene CDX2 in colon cancer as the starting point of their research. Using the CANDiT tool, they performed genomic scans on 4,600 different tumor samples. Through analysis, the team unexpectedly discovered a new treatment target—PRKAB1 protein, which functions to promote cell survival under stress conditions. Subsequently, they used existing drugs to activate PRKAB1, successfully restoring the function of the CDX2 gene in colon cancer stem cells.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 18px;\" class=\"ql-lineHeight-1-75\">However, these cancer stem cells seemed unable to tolerate the loss of their \"cancer identity,\" and instead of remaining in a normal cell state, they chose self-destruction.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-size: 18px;\" class=\"ql-lineHeight-1-75\">To verify the clinical potential of this method, the team expanded drug testing to patient-derived organoid models. They also developed a gene signature, a method that can predict a patient's response to this treatment through gene activation patterns. Through simulation analysis of over 2,100 patients, it was found that after the recovery of CDX2 gene function, the risk of recurrence and death in colon cancer patients could be reduced by 50%.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"color: rgb(187, 187, 187);\">[News Source] Science and Technology Daily \u003C\u002Fspan>\u003Ca href=\"http:\u002F\u002Fhealth.people.com.cn\u002Fn1\u002F2025\u002F1022\u002Fc14739-40586853.html\" rel=\"noopener noreferrer\" target=\"_blank\" style=\"color: rgb(187, 187, 187);\">http:\u002F\u002Fhealth.people.com.cn\u002Fn1\u002F2025\u002F1022\u002Fc14739-40586853.html\u003C\u002Fa>\u003C\u002Fp>\u003Cp class=\"ql-align-justify\">\u003Cspan style=\"color: rgb(187, 187, 187);\">（This article is reprinted by this site to provide readers with more information and news. The content involved does not constitute investment or consumption advice. If there are any questions about the facts of the article, please verify with the relevant parties. The views expressed in the article are not the views of this site and are for reference only.）\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>","https:\u002F\u002Fxinwei-dev-test.oss-cn-shenzhen.aliyuncs.com\u002Fintelligent\u002Faudio%3Aa7facaa1-853d-46b1-bca5-00cfa143c3f0%3A0.wav?Expires=1774838458&OSSAccessKeyId=LTAI5tNvY2RkKjZw4LLWsrPK&Signature=AQKRGF%2Foy6IjrPP935XToSUAhAY%3D","a7facaa1-853d-46b1-bca5-00cfa143c3f0",5517580]